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NO2 (nitric oxide) supplements are dietary supplements that may help to optimize the production of nitric oxide in the body. Nitric oxide is a gas that is naturally produced by the body and plays a key role in dilating blood vessels, improving blood flow, and regulating blood pressure. NO2 supplements typically contain ingredients such as L-arginine, L-citrulline, or nitrate, which are believed to help optimize nitric oxide production.